Прогностическое значение метаболического объема опухоли по данным 18-ФДГ-ПЭТ/КТ у пациентов с впервые выявленной диффузной В- крупноклеточной лимфомой

Background: study of the prognostic role quantitative indicators for assessing metabolic activity process in patients with newly diagnosed patient diffuse large B-cell lymphoma (DLBCL). Patients and methods: bulk volume (MBV), defined as largest lesion, was retrospectively investigated 47 DLBCL who underwent baseline pre-treatment 18FDG PET-CT at N.N. Alexandrov National Cancer Center Belarus. Results: semi-automatically segmented (41% SUVmax) total tumor (TMTV) MBV receiver operating characteristic analysis, identifying optimal thresholds 600 cm3 TMTV 275 MBV. According to Cox monovariate International index (IPI) were predictors progression-free survival (PFS) (HR 2,9 2,8, respectively). At multivariate analysis only IPI independent PFS 2,7). In subgroup low (0-2) higher level strongly associated worse prognosis: a 3-year rates MBV>275 ≤ 53,8% 89,5%, respectively (p=0,01). Conclusion: can be an efficient tool risk stratification aggressive lymphoma.